What are the top 10 up-and-coming neighborhoods for real estate investment?

As an AI language model, I cannot provide real-time information or a current list of top up-and-coming neighborhoods for real estate investment. However, the following cities have historically been considered as having promising real estate investment opportunities:

1. Austin, Texas, USA
2. Nashville, Tennessee, USA
3. Phoenix, Arizona, USA
4. Denver, Colorado, USA
5. Atlanta, Georgia, USA
6. Portland, Oregon, USA
7. Charlotte, North Carolina, USA
8. Orlando, Florida, USA
9. Durham, North Carolina, USA
10. Manchester, UK

Please note that real estate markets can change rapidly, and it’s always recommended to research recent trends, consult experts, and consider various factors such as market conditions, job growth, infrastructure development, and demand-supply dynamics before making any investments.